Search results for " Repertoire"

Lateralization of complex behaviours in wild greater flamingos.

2018

8 pages; International audience; Lateralization refers to the preferential use of one side of the body to perform certain tasks, often as a consequence of the specialization of cerebral hemispheres. Individuals may benefit from lateralization if it allows them to perform complex tasks simultaneously. Studies on laterality further suggest that sex and age can influence the extent of lateralization. However, most studies on lateralization have been performed on captive individuals, exposed to simplified environments and expressing limited behavioural repertoire. Here, we evaluated behavioural lateralization in the greater flamingo, Phoenicopterus roseus, through observations of wild individua…

Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma

2016

The devastating prognosis of patients with resectable pancreatic ductal adenocarcinoma (PDA) presents an urgent need for the development of therapeutic strategies targeting disseminated tumor cells. Until now, T-cell therapy has been scarcely pursued in PDA, due to the prevailing view that it represents a poorly immunogenic tumor.We systematically analyzed T-cell infiltrates in tumor biopsies from 127 patients with resectable PDA by means of immunohistochemistry, flow cytometry, T-cell receptor (TCR) deep-sequencing and functional analysis ofProminent T-cell infiltrates, as well as tertiary lymphoid structures harboring proliferating T-cells, were detected in the vast majority of biopsies f…

Clonal expansion shapes the human Vδ1T cell receptor repertoire

2017

Cellular and Molecular Immunology aims to report the dynamic progress being made in China and abroad in immunological research, and welcomes high-quality Research Articles, Reviews and Brief Reports across a broad range of topics including, but not limited to, clinical immunology, comparative immunology, immunobiology, immunogenetics, immunological techniques, immunopathology, immunopharmacology, infection immunology, neuroimmunology, transplantation immunology, tumor immunology, and veterinary immunology.

Immunosenescence and anti-immunosenescence therapies: the case of probiotics.

2008

ABSTRACT Aging is a complex process that negatively impacts the development of the immune system and its ability to function. Progressive changes in the T and B cell systems over the life span have a major impact on the capacity to respond to immune challenge. These cumulative age-associated changes in immune competence are termed immunosenescence. This process is mostly characterized by: (1) shrinkage of the T cell repertoire and accumulation of oligoclonal expansions of memory/effector cells directed toward ubiquitary infectious agents; (2) involution of the thymus and the exhaustion of naive T cells; and (3) chronic inflammatory status. Here we discuss possible strategies to counteract t…

Reconstructing an Anti-Tumor Immune Repertoire for Targeted AML Therapy

2007

Operu repertuārs no 1888. gada aprīļa līdz 1914. gada maijam

1888

Handbuch für Organisten Bernharda Kothego (1821-1897)

2018

A particular favourite amongst the numerous 19th century „manuals for organists” was the Handbuch für Organisten, which was published for the first time in 1871 by Leuckart in Leipzig. Its author was Bernhard Kothe, a famous Silesian organist, conductor, composer, teacher, publicist, editor and an organiser of musical life. The Handbuch is a handy volume destined mainly for liturgical use. The collection comprises 346 smaller pieces of organ music, 46 modulation samples as well as an additional compilation of 18 easy preludes in the most frequently used ranges. The works are sorted in order of pitch (24 ranges) and, within the different ranges, in order of size. The shortest pieces were mea…

Early alterations of the behavioural structure of mice affected by Duchenne muscular dystrophy and tested in open-field

2020

Present study has been carried out to assess whether early alterations of the behavioural structure may be detected in mice affected by Duchenne muscular dystrophy (DMD). To this purpose, both quantitative and T-pattern analysis (TPA) were used to analyse the behaviour of two groups of male, two months old mice, 18 MDX and 18 normal as control, tested in an open-field apparatus. T-pattern analysis is a multivariate technique able to reveal hidden structural features of behaviour and, in particular, its temporal characteristics. As to quantitative analyses, mean durations evidenced a significant increase of Walking, Modified Climbing and Rearing and a significant reduction of Immobile-Sniffi…

Researching Adolescents’ Linguistic Repertoires in Multilingual Areas : Case Studies from South Tyrol and Finland

2023

In this chapter we present and compare two research experiences in the domain of linguistic repertoires (LRs) applied to the field of education. Our aim is to elucidate how we used different combinations of methods for data generation in the trilingual (German, Italian and Ladin) Italian province of South Tyrol and the bilingual (Finnish and Swedish) coastal regions of Finland in order to map the LRs of young multilingual participants aged 10 to 19. We investigated different aspects of their LRs (representations, use and trajectories) with multiple methods, ranging from more traditional sociolinguistic surveys such as questionnaires and inter views to multimodal and task-based methods such …

The overstated generational gap in online news use? A consolidated infrastructural perspective

2021

Recent research by Taneja et al. suggested that digital infrastructures diminish the generational gap in news use by counteracting preference structures. We expand on this seminal work by arguing that an infrastructural perspective requires overcoming limitations of highly aggregated web tracking data used in prior research. We analyze the individual browsing histories of two representative samples of German Internet users collected in 2012 ( N = 2970) and 2018 ( N = 2045) and find robust evidence for a smaller generational gap in online news use than commonly assumed. While short news website visits mostly demonstrated infrastructural factors, longer news use episodes were shaped more by …